Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-7-[4-[4-(1,1-Dimethylethyl)Benzoyl]-1-Piperazinyl]-6-Fluoro-1,4-Dihydro-4-Oxo- is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is of significant value in the research and development of novel active pharmaceutical ingredients (APIs), particularly in the synthesis of potent antibacterial agents. It is primarily sought by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in medicinal chemistry. The compound's specific structural features make it a critical building block for developing next-generation therapeutics.

Application

• Pharmaceutical Intermediate: Key synthetic precursor in the development of novel quinolone and fluoroquinolone antibiotic candidates.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to optimize antibacterial potency and pharmacokinetic profiles.
• API Synthesis: Integral building block in the multi-step synthesis of complex target molecules for preclinical and clinical studies.
• Biochemical Tool Compound: Serves as a reference standard or inhibitor in microbiological and enzymatic assays to study bacterial DNA gyrase and topoisomerase IV.
• Fine Chemical Production: Employed in custom synthesis and contract manufacturing for specialized, high-value chemical entities.

Basic Information

Item	Details
Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-7-[4-[4-(1,1-Dimethylethyl)Benzoyl]-1-Piperazinyl]-6-Fluoro-1,4-Dihydro-4-Oxo-
CAS No.	1054110-47-2
Molecular Formula	C28H30FN3O3
Molecular Weight	475.56 g/mol
Synonyms	1-Cyclopropyl-7-[4-[4-(tert-butyl)benzoyl]piperazin-1-yl]-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 1-Cyclopropyl-6-fluoro-7-(4-(4-(tert-butyl)benzoyl)piperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-[(4-tert-butylbenzoyl)]-1-piperazinyl]-3-quinolinecarboxylic Acid; WCK 771 Intermediate; Advanced Fluoroquinolone Intermediate
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid derivative is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent control of residual solvents and impurities. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP-grade requirements. Specifications are aligned with ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C limits
Heavy Metals	≤ 20 ppm
Assay (on dried basis)	97.0% - 102.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.