Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-7-[4-(3-Methyl-2-Nitrobenzoyl)-1-Piperazinyl]-4-Oxo- is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly within the fluoroquinolone antibiotic class, where it serves as a key building block. It is essential for research institutions and pharmaceutical manufacturers engaged in the development and production of next-generation antibacterial agents.

Application

• Pharmaceutical Intermediate: Primary use as a sophisticated building block in the synthesis of new-generation fluoroquinolone antibiotics.
• Antibacterial Drug Development: Key precursor in R&D for novel compounds targeting resistant bacterial strains.
• Organic Synthesis Research: Valuable reagent for academic and industrial research exploring complex nitrogen-containing heterocycles and their biological activities.
• Process Chemistry: Used in scale-up and optimization studies for the commercial manufacturing of specialized APIs.
• Contract Manufacturing (CMO): Supplied to contract development and manufacturing organizations (CDMOs) for client-specific API production.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-7-[4-(3-Methyl-2-Nitrobenzoyl)-1-Piperazinyl]-4-Oxo-
CAS No.	1054010-70-6
Molecular Formula	C24H21FN4O5
Molecular Weight	464.45 g/mol
Synonyms	1-Cyclopropyl-6-fluoro-1,4-dihydro-7-[4-(3-methyl-2-nitrobenzoyl)-1-piperazinyl]-4-oxo-3-quinolinecarboxylic acid; 1-Cyclopropyl-6-fluoro-7-[4-(3-methyl-2-nitrobenzoyl)piperazin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 1054010-70-6; GSK-2140944 Intermediate; Gepotidacin Intermediate; Benzamide, 3-methyl-2-nitro-N-[1-(1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-3-quinolinyl)-4-piperidinyl]-; (Alternative structural naming)
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical pharmaceutical applications. Quality is verified through comprehensive analytical methods including HPLC, NMR, and MS to confirm identity, purity, and impurity profiles. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.