Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-4-Oxo-7-[4-(1-Oxo-3-Phenoxypropyl)-1-Piperazinyl]- is a high-purity, advanced pharmaceutical intermediate of significant commercial and research importance. This compound is a key synthetic precursor in the development of novel fluoroquinolone antibiotics, valued for its complex molecular architecture which enables targeted therapeutic activity. It is primarily required by pharmaceutical R&D laboratories, API (Active Pharmaceutical Ingredient) manufacturers, and fine chemical synthesis specialists focused on next-generation anti-infective agents.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of advanced fluoroquinolone antibiotic candidates.
• API (Active Pharmaceutical Ingredient) Development: Used in research and process development for novel antibacterial agents targeting resistant pathogens.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies to optimize potency and safety profiles.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and pilot-scale production of target drug molecules.
• Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical manufacturing.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-4-Oxo-7-[4-(1-Oxo-3-Phenoxypropyl)-1-Piperazinyl]-
CAS No.	1054010-62-6
Molecular Formula	C26H26FN3O5
Molecular Weight	479.50 g/mol
Synonyms	1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-(1-oxo-3-phenoxypropyl)-1-piperazinyl]-3-quinolinecarboxylic acid; 7-[4-(3-Phenoxypropionyl)piperazin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid; Garenoxacin Intermediate; Garenoxacin Carboxylic Acid Derivative; OPC-17116 Intermediate; T-3811 Intermediate; BMS-284756 Intermediate; 1-Cyclopropyl-6-fluoro-7-(4-(3-phenoxypropionyl)piperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical pharmaceutical applications. Quality is verified through comprehensive analytical testing including HPLC, NMR, and MS. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment. We support development under GMP-like conditions and can tailor specifications to meet the rigorous standards of FDA and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic); ensure the container is sealed under an inert atmosphere if opened. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.