Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-7-[4-[2-(2-Fluorophenoxy)Acetyl]-1-Piperazinyl]-1,4-Dihydro-4-Oxo- is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is a key synthetic precursor in the development of novel fluoroquinolone antibiotics, offering a critical building block for medicinal chemistry. It is primarily sought by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in antimicrobial drug discovery and process development.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of next-generation fluoroquinolone antibiotic candidates.
• Medicinal Chemistry Research: Used for structure-activity relationship (SAR) studies and the development of new antimicrobial agents with improved efficacy and safety profiles.
• Process Chemistry & Scale-Up: Serves as a key intermediate for process optimization and the commercial-scale manufacturing of active pharmaceutical ingredients (APIs).
• Reference Standard: Employed as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Biochemical Research: Used in studies targeting bacterial DNA gyrase and topoisomerase IV enzymes to understand mechanisms of action and resistance.
• Custom Synthesis: A starting material for the custom synthesis of novel quinoline derivatives for various therapeutic applications.

Basic Information

Item	Detail
Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-7-[4-[2-(2-Fluorophenoxy)Acetyl]-1-Piperazinyl]-1,4-Dihydro-4-Oxo-
CAS No.	1054010-46-6
Molecular Formula	C25H23F2N3O5
Molecular Weight	483.47 g/mol
Synonyms	1-Cyclopropyl-6-fluoro-7-[4-[2-(2-fluorophenoxy)acetyl]piperazin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-(2-(2-fluorophenoxy)acetyl)piperazin-1-yl)quinoline-3-carboxylic acid; 7-[4-[2-(2-Fluorophenoxy)acetyl]-1-piperazinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid; GSK-2140944 Intermediate; Gepotidacin Intermediate; Antibacterial Intermediate
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid derivative is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D and process chemistry. Certificates of Analysis (COA) with detailed chromatographic data are provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive and hygroscopic; therefore, handling under inert atmosphere and desiccated conditions is recommended for long-term storage.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.