Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-7-[4-(2,6-Dimethoxybenzoyl)-1-Piperazinyl]-6-Fluoro-1,4-Dihydro-4-Oxo- is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is critical for research and development in the synthesis of novel active pharmaceutical ingredients (APIs), particularly within the fluoroquinolone antibiotic class. It is essential for pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in antimicrobial drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of next-generation fluoroquinolone antibiotics and other therapeutic agents.
• Antimicrobial Research: Used in R&D for developing novel compounds targeting bacterial DNA gyrase and topoisomerase IV enzymes.
• Process Chemistry Development: Serves as a critical reference standard and starting material for optimizing scalable API synthesis routes.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for GMP-grade production of clinical trial materials.
• Academic & Institutional Research: Utilized in university and institutional labs for medicinal chemistry studies and structure-activity relationship (SAR) analysis.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-7-[4-(2,6-Dimethoxybenzoyl)-1-Piperazinyl]-6-Fluoro-1,4-Dihydro-4-Oxo-
CAS No.	1054009-74-3
Molecular Formula	C26H25FN3O5
Molecular Weight	478.49 g/mol
Synonyms	1-Cyclopropyl-7-[4-(2,6-dimethoxybenzoyl)piperazin-1-yl]-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 1-Cyclopropyl-6-fluoro-7-(4-(2,6-dimethoxybenzoyl)piperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; WCK 771 Intermediate; NXL 101 Intermediate; Advanced Fluoroquinolone Intermediate; 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-(2,6-dimethoxybenzoyl)-1-piperazinyl)-3-quinolinecarboxylic Acid
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid derivative is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent control of residual solvents and impurities. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with the exacting standards required for pharmaceutical R&D and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed in a desiccated environment and handled under appropriate conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Assay	97.0% - 102.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.