Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-7-[4-(3-Fluorobenzoyl)-1-Piperazinyl]-1,4-Dihydro-4-Oxo- is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is a key synthetic precursor in the development of novel fluoroquinolone antibiotics, valued for its precise molecular architecture that enables targeted pharmacological activity. It is primarily required by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and API producers engaged in the synthesis of next-generation antibacterial agents.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: Critical building block in the synthetic pathway for novel fluoroquinolone-class antibiotics.
• Pharmaceutical Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the discovery of new antibacterial compounds.
• Process Chemistry & Scale-Up: Serves as a key material for optimizing synthetic routes and scaling production from laboratory to pilot and commercial batches.
• Reference Standard: Employed as a high-purity analytical standard for quality control and regulatory submissions in drug development.
• Custom Synthesis: Starting material for the contract synthesis of specialized, non-commercial drug candidates and analogs for clinical trials.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-7-[4-(3-Fluorobenzoyl)-1-Piperazinyl]-1,4-Dihydro-4-Oxo-
CAS No.	1054009-50-5
Molecular Formula	C24H21F2N3O4
Molecular Weight	453.44 g/mol
Synonyms	1-Cyclopropyl-6-fluoro-7-[4-(3-fluorobenzoyl)piperazin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-(3-fluorobenzoyl)-1-piperazinyl)-3-quinolinecarboxylic acid; 7-[4-(3-Fluorobenzoyl)-1-piperazinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid; WCK 771 Intermediate; Advanced Fluoroquinolone Intermediate
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid derivative is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediate applications. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive and hygroscopic; appropriate handling procedures for moisture-sensitive materials are recommended.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.