Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-7-[4-(2-Naphthalenylcarbonyl)-1-Piperazinyl]-4-Oxo- is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is valued for its complex heterocyclic structure, which serves as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel fluoroquinolone antibiotic candidates and other biologically active molecules.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Synthesis: Serves as a core scaffold for constructing complex molecules targeting bacterial infections and other disease pathways.
• Chemical Reference Standard: Employed as a high-purity standard for analytical method development, validation, and quality control in pharmaceutical analysis.
• Process Chemistry: Utilized in scale-up and process optimization studies for the commercial manufacturing of target drug substances.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-7-[4-(2-Naphthalenylcarbonyl)-1-Piperazinyl]-4-Oxo-
CAS No.	1054009-34-5
Molecular Formula	C28H24FN3O4
Molecular Weight	485.51 g/mol
Synonyms	1-Cyclopropyl-6-fluoro-1,4-dihydro-7-[4-(2-naphthoyl)piperazin-1-yl]-4-oxoquinoline-3-carboxylic acid; 1-Cyclopropyl-6-fluoro-7-(4-(naphthalene-2-carbonyl)piperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 7-[4-(2-Naphthoyl)-1-piperazinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid; GSK 2140944 Intermediate; Gepotidacin Intermediate; GSK2140944 Intermediate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the exacting standards required for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) detailing batch-specific results are provided and can be tailored to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive; prolonged exposure should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.