Description

3-Quinolinecarboxylic Acid, 7-[4-(4-Chlorobenzoyl)-1-Piperazinyl]-1-Cyclopropyl-6-Fluoro-1,4-Dihydro-4-Oxo- is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is a key synthetic precursor in the development of novel fluoroquinolone-class antibacterial agents, valued for its precise molecular architecture. It is primarily required by pharmaceutical R&D laboratories, process development chemists, and manufacturers engaged in the synthesis of next-generation antibiotic APIs.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of advanced fluoroquinolone antibiotics.
• Antibacterial Drug Discovery: Used in medicinal chemistry research to develop new compounds targeting DNA gyrase and topoisomerase IV.
• Process Chemistry & Scale-Up: Serves as a key starting material (KSM) or intermediate in the optimization and commercial-scale production of active pharmaceutical ingredients (APIs).
• Reference Standard: Utilized as a high-purity analytical standard for quality control and regulatory submissions in drug development.
• Biochemical Research: Employed in studies investigating bacterial resistance mechanisms and the structure-activity relationships (SAR) of quinolone drugs.
• Custom Synthesis: Basis for the preparation of structurally related analogs for patent-busting or novel drug candidate libraries.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 7-[4-(4-Chlorobenzoyl)-1-Piperazinyl]-1-Cyclopropyl-6-Fluoro-1,4-Dihydro-4-Oxo-
CAS No.	1054009-18-5
Molecular Formula	C24H21ClFN3O3
Molecular Weight	453.90 g/mol
Synonyms	7-[4-(4-Chlorobenzoyl)piperazin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 1-Cyclopropyl-6-fluoro-7-(4-(4-chlorobenzoyl)piperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; WCK 771 Intermediate; Levonadifloxacin Intermediate; NADI-1; Benzoic acid, 4-chloro-, 4-(1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-3-quinolinecarbonyl)-1-piperazinyl ester (alternative form); Quinolone carboxylic acid derivative
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical pharmaceutical applications. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and MS. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment. We support development and commercial projects requiring compliance with ICH guidelines and customer-specific specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be light-sensitive and hygroscopic; therefore, containers should be kept sealed under an inert atmosphere when not in use to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.