Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-7-[4-(3-Nitrobenzoyl)-1-Piperazinyl]-4-Oxo- is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is of significant commercial importance for its role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly within the fluoroquinolone antibiotic class. It is primarily sought by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of next-generation antibacterial agents and other therapeutic molecules.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of novel fluoroquinolone antibiotics and other therapeutic agents.
• Antibacterial Drug Development: Used in the R&D pipeline for creating new molecules targeting resistant bacterial strains.
• Chemical Synthesis Research: Serves as a sophisticated precursor in academic and industrial laboratories for exploring new heterocyclic chemistry and reaction pathways.
• Active Pharmaceutical Ingredient (API) Manufacturing: Employed in the scaled-up production processes for target APIs under Good Manufacturing Practice (GMP) conditions.
• Process Chemistry & Optimization: Utilized by process chemists to develop efficient, scalable, and cost-effective synthetic routes for complex molecules.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-7-[4-(3-Nitrobenzoyl)-1-Piperazinyl]-4-Oxo-
CAS No.	1054009-10-7
Molecular Formula	C24H21FN4O5
Molecular Weight	464.45 g/mol
Synonyms	1-Cyclopropyl-6-fluoro-1,4-dihydro-7-[4-(3-nitrobenzoyl)-1-piperazinyl]-4-oxo-3-quinolinecarboxylic acid; 7-[4-(3-Nitrobenzoyl)-1-piperazinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid; 1-Cyclopropyl-6-fluoro-7-(4-(3-nitrobenzoyl)piperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; Gatifloxacin Nitrobenzoyl Piperazine Intermediate; Advanced Fluoroquinolone Intermediate; 1054009-10-7 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols suitable for pharmaceutical R&D and manufacturing. Every batch is subjected to comprehensive analytical testing, including HPLC for purity and impurity profiling, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring full traceability and compliance with your internal specifications and the principles of ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference
Purity (HPLC)	≥ 98.0%
Single Maximum Impurity	≤ 1.0%
Total Impurities	≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.