Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-4-Oxo-7-[4-[2-(Phenylthio)Acetyl]-1-Piperazinyl]- is a high-purity advanced pharmaceutical intermediate (API intermediate) with a complex heterocyclic structure. This compound is of critical importance for the research and development of novel antibacterial agents, particularly within the fluoroquinolone class. It is primarily required by pharmaceutical R&D laboratories, process development chemists, and manufacturers engaged in the synthesis of next-generation antibiotic candidates. The precise molecular architecture of this intermediate enables the exploration of new therapeutic pathways with potential activity against resistant bacterial strains.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel fluoroquinolone antibiotic candidates.
• Antimicrobial Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies to develop new antibacterial agents.
• Process Chemistry: Serves as a critical intermediate in the scale-up and optimization of API manufacturing processes.
• Contract Research & Development (CRO/CMO): Supplied to organizations specializing in custom synthesis and drug development services.
• Academic Research: Utilized in university and institutional labs for biochemical and pharmacological studies targeting bacterial enzymes.

Basic Information

Item	Details
Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-4-Oxo-7-[4-[2-(Phenylthio)Acetyl]-1-Piperazinyl]-
CAS No.	1053952-10-5
Molecular Formula	C25H23FN3O4S
Molecular Weight	480.53 g/mol
Synonyms	1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-[2-(phenylthio)acetyl]-1-piperazinyl]-3-quinolinecarboxylic acid; 7-[4-(2-Phenylthioacetyl)piperazin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; GSK-2140944 Intermediate; GSK2140944 Intermediate; Novel Fluoroquinolone Intermediate; Antibacterial API Intermediate; 1-Cyclopropyl-6-fluoro-7-(4-(2-(phenylthio)acetyl)piperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid derivative is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS), to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment. We adhere to cGMP principles where applicable to support our clients' regulatory and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.