Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-7-[4-[4-(Methoxycarbonyl)Benzoyl]-1-Piperazinyl]-4-Oxo- is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is a key synthetic precursor in the development of novel fluoroquinolone antibiotics, offering critical structural complexity for modern drug discovery. It is primarily utilized by pharmaceutical R&D laboratories, API (Active Pharmaceutical Ingredient) manufacturers, and fine chemical synthesis specialists.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of next-generation fluoroquinolone antibacterial agents.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core structural moiety in the research and process development of new antibiotic candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize antibacterial potency and spectrum.
• Process Chemistry & Scale-Up: Employed in the development and optimization of scalable synthetic routes for complex drug molecules.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory submissions in pharmaceutical manufacturing.
• Custom Synthesis: A starting material for the custom synthesis of specialized chemical entities for biological testing.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-7-[4-[4-(Methoxycarbonyl)Benzoyl]-1-Piperazinyl]-4-Oxo-
CAS No.	1053952-02-5
Molecular Formula	C26H24FN3O6
Molecular Weight	493.49 g/mol
Synonyms	1-Cyclopropyl-6-fluoro-1,4-dihydro-7-[4-[(4-methoxycarbonyl)benzoyl]-1-piperazinyl]-4-oxo-3-quinolinecarboxylic acid; 7-[4-(4-Methoxycarbonylbenzoyl)piperazin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; Fluoroquinolone Intermediate; Garenoxacin Intermediate; BMS-284756 Intermediate; T-3811 Intermediate; 1-Cyclopropyl-6-fluoro-7-(4-(4-(methoxycarbonyl)benzoyl)piperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols suitable for pharmaceutical applications. Each batch is manufactured under a quality management system and undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with customer specifications. We support development needs with custom purity grades and can align with cGMP standards as required for later-stage development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.