Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-7-[4-[2-(4-Ethoxyphenyl)Acetyl]-1-Piperazinyl]-6-Fluoro-1,4-Dihydro-4-Oxo- is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is a key synthetic precursor in the development of novel fluoroquinolone-class antibacterial agents, valued for its complex molecular architecture. It is primarily required by pharmaceutical R&D laboratories and API (Active Pharmaceutical Ingredient) manufacturers engaged in the synthesis of next-generation antibiotics.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel fluoroquinolone antibiotics targeting resistant bacterial strains.
• Research & Development: Used in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a core intermediate in multi-step GMP manufacturing processes for final drug substances.
• Biochemical Research: Employed as a tool compound in microbiological studies to investigate bacterial DNA gyrase and topoisomerase IV inhibition.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.
• Reference Standard: High-purity grades are utilized as analytical reference standards for quality control and regulatory submissions.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-7-[4-[2-(4-Ethoxyphenyl)Acetyl]-1-Piperazinyl]-6-Fluoro-1,4-Dihydro-4-Oxo-
CAS No.	1053951-70-4
Molecular Formula	C25H26FN3O4
Molecular Weight	451.49 g/mol
Synonyms	1-Cyclopropyl-7-[4-[2-(4-ethoxyphenyl)acetyl]-1-piperazinyl]-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid; 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-(2-(4-ethoxyphenyl)acetyl)piperazin-1-yl)quinoline-3-carboxylic acid; Fluoroquinolone Intermediate 1053951-70-4; GSK-2140944 Intermediate; 7-(4-(2-(4-Ethoxyphenyl)acetyl)piperazin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid intermediate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, residual solvent analysis, and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen) when not in use to prevent degradation and ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.