Description

3-Quinolinecarboxylic Acid, 7-[4-[2-(4-Cyanophenoxy)Acetyl]-1-Piperazinyl]-1-Cyclopropyl-6-Fluoro-1,4-Dihydro-4-Oxo- is a high-purity advanced pharmaceutical intermediate of significant commercial and research interest. This compound is critical for the synthesis of novel fluoroquinolone antibiotics, offering a key structural moiety for developing next-generation antimicrobial agents. It is primarily utilized by pharmaceutical R&D departments and fine chemical manufacturers engaged in the development of active pharmaceutical ingredients (APIs) targeting resistant bacterial infections.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel fluoroquinolone antibiotic candidates.
• Antimicrobial Research: Used in medicinal chemistry programs to develop new compounds with activity against drug-resistant bacteria.
• API Development: Serves as a critical precursor in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs).
• Chemical Synthesis: Employed in organic synthesis for constructing complex heterocyclic systems with biological activity.
• Biochemical Research: Used as a reference standard or tool compound in studies of bacterial DNA gyrase and topoisomerase IV inhibition.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 7-[4-[2-(4-Cyanophenoxy)Acetyl]-1-Piperazinyl]-1-Cyclopropyl-6-Fluoro-1,4-Dihydro-4-Oxo-
CAS No.	1053951-42-0
Molecular Formula	C26H24FN5O5
Molecular Weight	505.50 g/mol
Synonyms	7-[4-[2-(4-Cyanophenoxy)acetyl]piperazin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; WCK 771 Intermediate; Levonadifloxacin Intermediate; Levonadifloxacin Alalevonadifloxacin Precursor; (S)-(-)-9-Fluoro-6,7-dihydro-8-(4-hydroxy-1-piperazinyl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid L-alanine ester derivative intermediate; 1-Cyclopropyl-7-[4-[2-(4-cyanophenoxy)acetyl]piperazin-1-yl]-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; Alalevonadifloxacin related compound.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols suitable for pharmaceutical development. Certificates of Analysis (COA) are provided with each batch, detailing purity, identity, and impurity profiles. Quality is assured through comprehensive analytical techniques including HPLC, NMR, and MS, ensuring consistency and traceability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.