Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-7-[4-[2-(2,5-Dimethylphenoxy)Acetyl]-1-Piperazinyl]-6-Fluoro-1,4-Dihydro-4-Oxo- is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound matters as a critical building block in the synthesis of novel fluoroquinolone antibiotics, offering researchers and manufacturers a reliable route to develop next-generation antimicrobial agents. It is primarily needed by pharmaceutical R&D laboratories and active pharmaceutical ingredient (API) producers focused on anti-infective drug discovery and development.

Application

• Pharmaceutical Intermediate: Key synthetic precursor for the development of new-generation fluoroquinolone antibiotic candidates.
• Antimicrobial Research: Serves as a core scaffold in medicinal chemistry programs targeting DNA gyrase and topoisomerase IV inhibition.
• API Synthesis: Used in the multi-step manufacturing process of complex antibiotic active pharmaceutical ingredients (APIs).
• Chemical Reference Standard: Provides a high-purity standard for analytical method development, quality control, and regulatory submissions.
• Structure-Activity Relationship (SAR) Studies: Enables the exploration of modifications to the quinoline and piperazinyl rings to optimize potency and pharmacokinetic properties.
• Process Chemistry Development: Used for scaling up and optimizing synthetic routes in pilot plants and commercial production.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-7-[4-[2-(2,5-Dimethylphenoxy)Acetyl]-1-Piperazinyl]-6-Fluoro-1,4-Dihydro-4-Oxo-
CAS No.	1053951-34-0
Molecular Formula	C27H27FN4O5
Molecular Weight	506.53 g/mol
Synonyms	1-Cyclopropyl-6-fluoro-7-(4-[(2,5-dimethylphenoxy)acetyl]piperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 1-Cyclopropyl-7-[4-[2-(2,5-dimethylphenoxy)acetyl]piperazin-1-yl]-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; Fluoroquinolone Intermediate; Garenoxacin Intermediate; AM-1155 Intermediate; T-3811 Intermediate; BMS-284756 Intermediate
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid derivative is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) with batch-specific data are provided to support your R&D and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed in a desiccated environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.2%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.