Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-7-[4-[(2,3-Dihydro-1,4-Benzodioxin-6-Yl)Carbonyl]-1-Piperazinyl]-6-Fluoro-1,4-Dihydro-4-Oxo- is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is of significant commercial interest for its critical role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the fluoroquinolone antibiotic class. It is essential for research institutions and pharmaceutical manufacturers engaged in the development of next-generation antibacterial agents and other therapeutic molecules.

Application

• Key Intermediate for Antibiotic Synthesis: Primarily used in the research and production of advanced fluoroquinolone antibiotics.
• Pharmaceutical R&D: Serves as a crucial building block in medicinal chemistry for creating new chemical entities with potential antibacterial activity.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and pilot-scale manufacturing of target drug candidates.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-7-[4-[(2,3-Dihydro-1,4-Benzodioxin-6-Yl)Carbonyl]-1-Piperazinyl]-6-Fluoro-1,4-Dihydro-4-Oxo-
CAS No.	1053951-10-2
Molecular Formula	C26H24FN3O5
Molecular Weight	477.49 g/mol
Synonyms	1-Cyclopropyl-6-fluoro-7-(4-(2,3-dihydrobenzo[b][1,4]dioxine-6-carbonyl)piperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; WCK 771; WCK-771; ABT 492; ABT-492; Nacubactam Intermediate; Diazabicyclooctane β-Lactamase Inhibitor Intermediate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict cGMP (current Good Manufacturing Practice) guidelines to ensure batch-to-batch consistency and traceability. Quality is verified through a comprehensive suite of analytical techniques including HPLC, NMR, and LC-MS to confirm identity, purity, and the absence of critical impurities. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic; therefore, containers should be kept tightly sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity	≤ 0.5%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.