Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-7-[4-(4-Ethylbenzoyl)-1-Piperazinyl]-6-Fluoro-1,4-Dihydro-4-Oxo- is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is a key synthetic precursor in the development of novel fluoroquinolone antibiotics and other active pharmaceutical ingredients (APIs). It is essential for pharmaceutical R&D laboratories, process development chemists, and manufacturers engaged in the synthesis of next-generation antibacterial agents. The product is supplied under strict quality control to ensure batch-to-batch consistency for critical applications.

Application

• Pharmaceutical Intermediate: Primary building block for the synthesis of novel fluoroquinolone antibiotic candidates.
• Active Pharmaceutical Ingredient (API) Development: Used in research and process development for new antibacterial drugs.
• Chemical Synthesis Research: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies.
• Process Chemistry & Scale-Up: Critical for optimizing synthetic routes from laboratory to pilot and commercial scale production.
• Reference Standard: Used as an analytical standard for quality control and regulatory submissions in pharmaceutical manufacturing.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Item	Details
Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-7-[4-(4-Ethylbenzoyl)-1-Piperazinyl]-6-Fluoro-1,4-Dihydro-4-Oxo-
CAS No.	1053950-79-0
Molecular Formula	C26H26FN3O3
Molecular Weight	447.51 g/mol
Synonyms	1-Cyclopropyl-7-[4-(4-ethylbenzoyl)piperazin-1-yl]-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-(4-ethylbenzoyl)-1-piperazinyl)-3-quinolinecarboxylic Acid; WCK 2349 (Free Acid); WCK-2349; WCK2349; 7-[4-(4-Ethylbenzoyl)-1-piperazinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid; (1-Cyclopropyl-6-fluoro-4-oxo-7-{4-[(4-ethylphenyl)carbonyl]piperazin-1-yl}-1,4-dihydroquinolin-3-yl)carboxylic acid
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid derivative is manufactured under a quality management system in compliance with cGMP guidelines for pharmaceutical intermediates. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets stringent specifications. Comprehensive Certificates of Analysis (COA) detailing purity, related substances, and residual solvents are provided with every shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.