Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-7-[4-(2,4-Difluorobenzoyl)-1-Piperazinyl]-6-Fluoro-1,4-Dihydro-4-Oxo- is a high-purity, advanced pharmaceutical intermediate of significant commercial and research importance. This compound is a key synthetic precursor in the development of novel fluoroquinolone antibiotics, offering critical structural complexity for targeting resistant bacterial strains. It is essential for pharmaceutical R&D laboratories, process chemists, and manufacturers engaged in the synthesis of next-generation antibacterial agents and other fine chemical products.

Application

• Pharmaceutical Intermediate: Primary use as a critical building block in the synthesis of novel fluoroquinolone antibiotic candidates.
• Antibacterial Drug Development: Serves as a core scaffold for research into new antibacterial agents with improved efficacy against drug-resistant bacteria.
• Process Chemistry & Scale-Up: Used in route scouting, optimization, and pilot-scale manufacturing for active pharmaceutical ingredients (APIs).
• Biochemical Research: Employed in studies investigating structure-activity relationships (SAR) of quinolone-based compounds.
• Fine Chemical Synthesis: A versatile intermediate for synthesizing complex molecules with the quinoline core for various specialty chemical applications.
• Contract Manufacturing (CMO): Supplied to contract development and manufacturing organizations (CDMOs) for cGMP production of clinical trial materials.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-7-[4-(2,4-Difluorobenzoyl)-1-Piperazinyl]-6-Fluoro-1,4-Dihydro-4-Oxo-
CAS No.	1053950-51-8
Molecular Formula	C24H20F3N3O3
Molecular Weight	455.43 g/mol
Synonyms	1-Cyclopropyl-7-[4-(2,4-difluorobenzoyl)piperazin-1-yl]-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 1-Cyclopropyl-6-fluoro-7-(4-(2,4-difluorobenzoyl)piperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; WCK 771 Intermediate; Advanced Fluoroquinolone Intermediate; 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-(2,4-difluorobenzoyl)-1-piperazinyl)-3-quinolinecarboxylic Acid
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid derivative is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent control of residual solvents and impurities. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or cGMP requirements. We adhere to ICH guidelines for stability and impurity profiling.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Assay	97.0% - 102.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.