Description

3-Quinolinecarboxylic Acid, 7-[4-(Cyclohexylcarbonyl)-1-Piperazinyl]-1-Cyclopropyl-6-Fluoro-1,4-Dihydro-4-Oxo- is a high-purity advanced pharmaceutical intermediate (API intermediate) with significant commercial and research value. This compound is critical for the synthesis of novel fluoroquinolone antibiotics, offering a key structural moiety for developing potent antimicrobial agents. It is primarily required by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and bulk API producers engaged in the development of next-generation antibacterial therapeutics.

Application

• Key Intermediate for Fluoroquinolone Antibiotics: Serves as a core building block in the synthesis of novel broad-spectrum antibacterial agents.
• Pharmaceutical Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization programs targeting bacterial infections.
• Active Pharmaceutical Ingredient (API) Manufacturing: Employed in the scaled-up production of proprietary antibiotic compounds under cGMP conditions.
• Contract Synthesis: Supplied to CROs and CMOs for custom synthesis and process development projects.
• Biochemical Research: Utilized as a tool compound in microbiological studies to investigate bacterial DNA gyrase and topoisomerase IV inhibition mechanisms.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 7-[4-(Cyclohexylcarbonyl)-1-Piperazinyl]-1-Cyclopropyl-6-Fluoro-1,4-Dihydro-4-Oxo-
CAS No.	1053950-27-8
Molecular Formula	C24H28FN3O4
Molecular Weight	441.50 g/mol
Synonyms	7-[4-(Cyclohexylcarbonyl)piperazin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 1-Cyclopropyl-6-fluoro-7-(4-piperazinyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid cyclohexylcarbonyl derivative; 1053950-27-8; Fluoroquinolone Intermediate; Quinolone Carboxylic Acid Derivative; Garenoxacin Intermediate (related); Advanced Fluoroquinolone Building Block
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality systems suitable for pharmaceutical applications. Every batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets exacting customer specifications. Certificates of Analysis (COA) detailing all test results are provided and can be tailored to support regulatory filings. We operate with a commitment to quality standards relevant to API intermediate manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.