Description

N'-[1-Amino-1-(3,5-Bis-(Trifluoromethyl)Phenyl)Methylidene]Hydrazinecarboxylic Acid tert-Butyl Ester is a high-purity, specialized organic intermediate featuring a unique trifluoromethylphenyl hydrazinecarboxylate structure. This compound matters for its role as a critical building block in the synthesis of complex molecules, particularly in advanced pharmaceutical and agrochemical research where the introduction of fluorine atoms is key to modulating biological activity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases, where the trifluoromethyl groups enhance lipophilicity and metabolic resistance.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging its structural motif to improve efficacy and environmental profile.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of specialty polymers, coatings, and liquid crystals that require fluorinated aromatic components for specific thermal or chemical resistance properties.
• Chemical Biology & Proteomics: Employed as a reactive handle or linker in the design of chemical probes, activity-based protein profiling (ABPP) agents, and bioconjugation tools due to its hydrazine and ester functionalities.
• Catalyst & Ligand Development: Acts as a precursor for nitrogen-containing ligands used in transition metal catalysis for cross-coupling and other synthetic transformations.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client-specific research programs.

Basic Information

Product Name	N'-[1-Amino-1-(3,5-Bis-(Trifluoromethyl)Phenyl)Methylidene]Hydrazinecarboxylic Acid tert-Butyl Ester
CAS No.	1053655-95-0
Molecular Formula	C15H15F6N3O2
Molecular Weight	383.29 g/mol
Synonyms	tert-Butyl (2Z)-2-[(3,5-bis(trifluoromethyl)phenyl)(imino)methyl]hydrazine-1-carboxylate; 1,1-Dimethylethyl N-[(1Z)-1-amino-1-[3,5-bis(trifluoromethyl)phenyl]methylene]hydrazinecarboxylate; tert-Butyl (Z)-[amino(3,5-bis(trifluoromethyl)phenyl)methylene]carbazate; 1053655-95-0; (Z)-tert-Butyl (amino(3,5-bis(trifluoromethyl)phenyl)methylene)carbazate; Hydrazinecarboxylic acid, N'-[1-amino-1-[3,5-bis(trifluoromethyl)phenyl]methylene]-, 1,1-dimethylethyl ester, (Z)-; BRN 27505835
EINECS	Contact for details

Quality Control

Our N'-[1-Amino-1-(3,5-Bis-(Trifluoromethyl)Phenyl)Methylidene]Hydrazinecarboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced synthetic intermediates. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and MS is provided with each shipment. We support cGMP standards for pharmaceutical applications and can tailor specifications to meet specific project needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.