Description

5-(Trifluoromethoxy)Pyridin-2-Ol is a high-value fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique trifluoromethoxy-substituted pyridinol structure offers significant advantages in modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries seeking to incorporate fluorine-containing motifs into novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) drugs and kinase inhibitors.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances biological activity and environmental persistence.
• Material Science: Building block for creating specialty polymers, liquid crystals, and organic electronic materials requiring specific fluorine-based properties.
• Chemical Research: Versatile reagent in medicinal chemistry for structure-activity relationship (SAR) studies and the exploration of novel heterocyclic compounds.
• Ligand & Catalyst Development: Potential precursor for synthesizing novel ligands used in catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	5-(Trifluoromethoxy)Pyridin-2-Ol
CAS No.	1052722-33-4
Molecular Formula	C6H4F3NO2
Molecular Weight	179.10 g/mol
Synonyms	2-Hydroxy-5-(trifluoromethoxy)pyridine; 5-(Trifluoromethoxy)-2-pyridinol; 2-Pyridinol, 5-(trifluoromethoxy)-; 5-Trifluoromethoxypyridin-2-ol; 2-Hydroxy-5-trifluoromethoxypyridine; 5-(Trifluoromethoxy)-2-hydroxypyridine; 5-(Trifluoromethoxy)pyridin-2(1H)-one (tautomer)
EINECS	Contact for details

Quality Control

Our 5-(Trifluoromethoxy)Pyridin-2-Ol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents. The container should be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.