Description

1-(4-Nitro-3-Pyrrolidin-1-Yl-Phenyl)-Piperazine, Hydrochloride is a high-purity, non-racemic pharmaceutical intermediate of significant importance in modern drug discovery and development. This compound matters for its role as a key building block in the synthesis of complex, biologically active molecules, particularly those targeting central nervous system (CNS) disorders. Pharmaceutical R&D teams and fine chemical manufacturers need it to ensure the reliable and scalable production of novel therapeutic candidates, where consistent quality and structural integrity are paramount.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel drug candidates, particularly for CNS-targeted therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes to develop new pharmacologically active entities.
• Contract Development and Manufacturing (CDMO): Sourced by CDMOs for the cGMP-compliant production of active pharmaceutical ingredients (APIs) for clinical trials and commercial supply.
• Biochemical Tool Compound: May serve as a research tool for investigating specific biological pathways and receptor interactions in academic and industrial laboratories.
• Precursor for Chiral Synthesis: Its structure makes it valuable for the development of enantiomerically pure compounds, which are essential for many modern drugs.

Basic Information

Product Name	1-(4-Nitro-3-Pyrrolidin-1-Yl-Phenyl)-Piperazine, Hydrochloride
CAS No.	1052148-98-7
Molecular Formula	C15H21N5O2 • HCl
Molecular Weight	355.82 g/mol (as hydrochloride salt)
Synonyms	1-[4-Nitro-3-(1-pyrrolidinyl)phenyl]piperazine hydrochloride; 1-(4-Nitro-3-pyrrolidin-1-ylphenyl)piperazine HCl; 1-(3-Pyrrolidin-1-yl-4-nitrophenyl)piperazine hydrochloride; 1052148-98-7; Piperazine, 1-[4-nitro-3-(1-pyrrolidinyl)phenyl]-, hydrochloride (1:1); UNII-8I3Q1J3Y1C; 8I3Q1J3Y1C
EINECS	Contact for details

Quality Control

Our production of 1-(4-Nitro-3-Pyrrolidin-1-Yl-Phenyl)-Piperazine, Hydrochloride adheres to stringent quality management systems, ensuring batch-to-batch consistency suitable for demanding pharmaceutical applications. All material is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We are committed to meeting the exacting standards required for cGMP intermediates, with specifications that can be aligned to client-specific pharmacopeial requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider the use of desiccants.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area%)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity	≤ 0.5%
Total Impurities	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.