Description

3-Quinolinecarboxylic Acid, 7-[4-(4-Chloro-2-Fluorobenzoyl)-1-Piperazinyl]-1-Cyclopropyl-6-Fluoro-1,4-Dihydro-4-Oxo- is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This complex heterocyclic compound is valued for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily targeted at the pharmaceutical R&D and manufacturing sectors, where it is used to develop next-generation therapeutic agents, particularly in the fields of anti-infectives and specialized small-molecule drugs.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel quinolone and fluoroquinolone-based active pharmaceutical ingredients (APIs).
• Antibacterial Drug Research: Serves as a core scaffold for developing new antibacterial agents targeting resistant bacterial strains.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Contract Manufacturing (CMO): Supplied to contract development and manufacturing organizations (CDMOs) for cGMP production of clinical trial materials and commercial APIs.
• Biochemical Research: Employed as a tool compound in biochemical assays to study enzyme inhibition and bacterial gyrase/topoisomerase mechanisms.
• Reference Standard: Used as a high-purity analytical reference standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 7-[4-(4-Chloro-2-Fluorobenzoyl)-1-Piperazinyl]-1-Cyclopropyl-6-Fluoro-1,4-Dihydro-4-Oxo-
CAS No.	1051248-99-7
Molecular Formula	C24H21ClF2N3O3
Molecular Weight	472.89 g/mol
Synonyms	7-[4-(4-Chloro-2-fluorobenzoyl)piperazin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 1-Cyclopropyl-6-fluoro-7-[4-(4-chloro-2-fluorobenzoyl)-1-piperazinyl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid; Intermediate for ABT-492 (Zabofloxacin); Zabofloxacin Intermediate; DW-224a Intermediate; Quinolone Carboxylic Acid Derivative; 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-(4-chloro-2-fluorobenzoyl)piperazin-1-yl)quinoline-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid derivative is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets exacting standards suitable for pharmaceutical R&D and cGMP applications. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical methods is provided with every shipment to ensure full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.