Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-7-[4-[2-(4-Methylphenyl)Acetyl]-1-Piperazinyl]-4-Oxo- is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. Its complex molecular architecture makes it a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly within the fluoroquinolone antibiotic class. This compound is essential for pharmaceutical R&D laboratories and manufacturers focused on developing next-generation antibacterial agents and exploring new therapeutic pathways.

Application

• Key Intermediate for Fluoroquinolone Antibiotics: Serves as a sophisticated precursor in the multi-step synthesis of potent antibacterial agents targeting DNA gyrase and topoisomerase IV.
• Pharmaceutical Research & Development: Used in medicinal chemistry programs for structure-activity relationship (SAR) studies and the development of new chemical entities with enhanced efficacy and safety profiles.
• Active Pharmaceutical Ingredient (API) Synthesis: Integral in the production scale-up of proprietary antibiotic compounds for clinical and commercial use.
• Process Chemistry & Optimization: Employed by process chemists to develop and refine efficient, scalable, and cost-effective synthetic routes for complex molecules.
• Reference Standard: Used as a high-purity analytical standard for quality control, method development, and regulatory submissions in pharmaceutical manufacturing.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-7-[4-[2-(4-Methylphenyl)Acetyl]-1-Piperazinyl]-4-Oxo-
CAS No.	1051224-24-8
Molecular Formula	C25H24FN3O4
Molecular Weight	449.48 g/mol
Synonyms	1-Cyclopropyl-6-fluoro-1,4-dihydro-7-[4-[2-(4-methylphenyl)acetyl]-1-piperazinyl]-4-oxo-3-quinolinecarboxylic acid; 7-[4-(2-p-Tolylacetyl)piperazin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 1-Cyclopropyl-6-fluoro-7-(4-(2-(4-methylphenyl)acetyl)piperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; Gatifloxacin Intermediate; Advanced Gatifloxacin Precursor; 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid derivative
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity suitable for pharmaceutical applications. Quality is verified through a comprehensive suite of analytical techniques including HPLC, NMR, and MS. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles. We support compliance with cGMP and ICH Q7 guidelines for active pharmaceutical ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.