Description

1,6-Naphthyridine-3-Carboxamide, 4-(4-Cyano-2-Methoxyphenyl)-5-Ethoxy-1,4-Dihydro-2,8-Dimethyl-, (4R)- is a high-purity, stereochemically defined advanced pharmaceutical intermediate. This compound is critical for research and development in medicinal chemistry, particularly for its role as a key building block in synthesizing novel therapeutic agents. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new active pharmaceutical ingredients (APIs) with complex heterocyclic structures.

Application

• Pharmaceutical Intermediate: Serves as a crucial chiral building block in the synthesis of potential drug candidates, especially in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes due to its complex naphthyridine core.
• API Development: A key starting material or intermediate in the multi-step synthesis of novel Active Pharmaceutical Ingredients (APIs).
• Preclinical & Clinical Trial Material Manufacturing: Supplied for the production of batches required for toxicology studies and early-phase clinical trials.
• Chemical Reference Standard: Can be utilized as a high-purity standard for analytical method development and validation in quality control laboratories.
• Academic & Institutional Research: Used in universities and research institutes for exploring new chemical entities and reaction methodologies.

Basic Information

Product Name	1,6-Naphthyridine-3-Carboxamide, 4-(4-Cyano-2-Methoxyphenyl)-5-Ethoxy-1,4-Dihydro-2,8-Dimethyl-, (4R)-
CAS No.	1050477-30-9
Molecular Formula	C22H24N4O3
Molecular Weight	392.45 g/mol
Synonyms	(4R)-4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-1,4-dihydro-2,8-dimethyl-1,6-naphthyridine-3-carboxamide; (4R)-4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide; 1,6-Naphthyridine-3-carboxamide, 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-1,4-dihydro-2,8-dimethyl-, (4R)-; UNII-8V7J3Q8J4F; 8V7J3Q8J4F; 1050477-30-9; (R)-4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity suitable for pharmaceutical development. Quality is verified through a comprehensive suite of analytical techniques including HPLC, GC, NMR, and MS. A Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles is provided with each shipment. We support compliance with ICH Q7 guidelines and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0%; Any single unknown impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.