Description

(S)-2-(tert-Butoxycarbonylamino-Methyl)-3-(1H-Indol-3-Yl)-Propionic Acid is a high-purity, non-natural amino acid derivative featuring a protected amine group and an indole side chain. This compound is a critical chiral building block for the synthesis of complex peptides and peptidomimetics, offering precise stereochemical control. It is essential for researchers and manufacturers in the pharmaceutical industry developing novel therapeutic agents, particularly in oncology and neurology.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the solid-phase and solution-phase synthesis of biologically active peptides and constrained peptidomimetics.
• Drug Discovery & Development: Used in medicinal chemistry for constructing libraries of novel compounds targeting GPCRs, enzymes, and protein-protein interactions.
• API Synthesis: Serves as a crucial building block in the multi-step synthesis of potential Active Pharmaceutical Ingredients (APIs), especially those containing tryptophan analogs.
• Bioconjugation & Probe Development: The Boc-protected amine allows for selective deprotection and further functionalization, useful for creating fluorescent probes or antibody-drug conjugates (ADCs).
• Academic & Contract Research: Employed in university and CRO laboratories for research in organic synthesis, asymmetric catalysis, and chemical biology.

Basic Information

Product Name	(S)-2-(tert-Butoxycarbonylamino-Methyl)-3-(1H-Indol-3-Yl)-Propionic Acid
CAS No.	1050443-69-0
Molecular Formula	C18H24N2O4
Molecular Weight	332.40 g/mol
Synonyms	(S)-2-((tert-Butoxycarbonylamino)methyl)-3-(1H-indol-3-yl)propanoic acid; Boc-(S)-3-(3-Indolyl)-alanine-OH; (S)-2-((Boc-amino)methyl)-3-(1H-indol-3-yl)propanoic acid; (S)-3-(1H-Indol-3-yl)-2-((((2-methylpropan-2-yl)oxy)carbonyl)amino)propanoic acid; Boc-DL-3-(3-Indolyl)alanine; N-Boc-3-(3-indolyl)-L-alanine; N-[(tert-Butoxy)carbonyl]-3-(1H-indol-3-yl)-L-alanine
EINECS	Contact for details

Quality Control

Our (S)-2-(tert-Butoxycarbonylamino-Methyl)-3-(1H-Indol-3-Yl)-Propionic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure compliance with research and development standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.