Description

4-Borono-2-(Trifluoromethyl)Benzoic Acid is a high-value, multifunctional aromatic building block that integrates a boronic acid and a carboxylic acid group on a trifluoromethylated benzene core. This unique structure makes it a critical intermediate for the synthesis of complex molecules, particularly in pharmaceutical research and advanced material science. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel active compounds and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for Suzuki-Miyaura cross-coupling reactions in the synthesis of drug candidates, especially those targeting CNS disorders, inflammation, and oncology.
• Agrochemical Research: Used in the development of novel herbicides and pesticides, leveraging the trifluoromethyl group for enhanced biological activity and metabolic stability.
• Material Science Precursor: Serves as a monomer or functionalizing agent for creating advanced polymers, metal-organic frameworks (MOFs), and organic electronic materials.
• Chemical Biology Probes: Utilized in the design and synthesis of activity-based probes and molecular sensors due to its dual reactive handles.
• Ligand Synthesis: Acts as a precursor for bidentate ligands used in catalysis and metal complexation.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	4-Borono-2-(Trifluoromethyl)Benzoic Acid
CAS No.	1050424-03-7
Molecular Formula	C8H6BF3O4
Molecular Weight	233.94 g/mol
Synonyms	2-(Trifluoromethyl)-4-boronobenzoic Acid; 4-Carboxy-3-(trifluoromethyl)phenylboronic Acid; Benzoic acid, 4-borono-2-(trifluoromethyl)-; 4-Borono-2-trifluoromethylbenzoic Acid; [4-Carboxy-3-(trifluoromethyl)phenyl]boronic Acid; 3-Trifluoromethyl-4-carboxyphenylboronic Acid; B-[4-Carboxy-3-(trifluoromethyl)phenyl]boronic Acid
EINECS	Contact for details

Quality Control

Every batch of 4-Borono-2-(Trifluoromethyl)Benzoic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive applications like pharmaceutical R&D. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters including purity (by HPLC), identity confirmation (by 1H/19F/11B NMR and IR), and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.