Description

n-(4-Methylbenzyl)-2-Propyn-1-Amine Hydrochloride is a high-purity organic building block and pharmaceutical intermediate of significant interest in modern synthetic chemistry. Its value lies in its unique molecular structure, which incorporates both a propargyl amine and a substituted benzyl group, making it a versatile synthon for constructing complex nitrogen-containing heterocycles and targeted bioactive molecules. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for lead optimization and process development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting neurological disorders, oncology, and infectious diseases.
• Agrochemical Research: Used in the development of new pesticides, herbicides, and plant growth regulators that require specific amine-based architectures.
• Chemical Biology & Proteomics: Serves as a valuable building block for creating chemical probes, affinity tags, and linkers used in activity-based protein profiling (ABPP) and bioconjugation.
• Material Science: Employed in the research of advanced polymers, resins, and coatings where its amine and alkyne functionalities can enable cross-linking or post-polymerization modification.
• Academic & Contract Research: A critical reagent for methodological development in organic synthesis, including click chemistry, Sonogashira coupling, and other catalytic transformations.

Basic Information

Product Name	n-(4-Methylbenzyl)-2-Propyn-1-Amine Hydrochloride
CAS No.	1050167-11-7
Molecular Formula	C11H14ClN
Molecular Weight	195.69 g/mol
Synonyms	1-(4-Methylbenzyl)-2-propyn-1-amine hydrochloride; N-(4-Methylbenzyl)prop-2-yn-1-amine hydrochloride; Propargyl-(4-methylbenzyl)amine hydrochloride; 4-Methylbenzylpropargylamine HCl; N-(p-Tolylmethyl)prop-2-yn-1-amine hydrochloride; N-(4-Methylbenzyl)propagylamine hydrochloride; (4-Methylbenzyl)(prop-2-yn-1-yl)amine hydrochloride
EINECS	Contact for details

Quality Control

Our n-(4-Methylbenzyl)-2-Propyn-1-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, which includes data from HPLC, NMR, and other relevant spectroscopic and chromatographic methods to confirm compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive). For long-term storage, consider using desiccants or storing under an inert atmosphere to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.