Description

(3S,4R)-4-(3-Fluorophenyl)Pyrrolidine-3-Carboxylic Acid is a high-purity, chiral pyrrolidine derivative that serves as a critical building block in modern synthetic chemistry. This compound matters for its role as a sophisticated intermediate in the development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and metabolic disorder research. Pharmaceutical R&D teams and fine chemical manufacturers need this material for constructing complex molecular architectures where stereochemical control and fluorine substitution are paramount for biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates targeting neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore the impact of fluorinated, constrained pyrrolidine scaffolds on potency and selectivity.
• Asymmetric Synthesis: Employed as a chiral auxiliary or ligand precursor in catalytic asymmetric transformations.
• Peptidomimetics Development: Incorporated into peptide backbones to enhance stability, bioavailability, and receptor binding affinity.
• Chemical Biology Probes: Serves as a core structure for developing tool compounds and probes to study enzyme function and biological pathways.
• Agrochemical Research: Potential intermediate for developing advanced crop protection agents with improved environmental profiles.

Basic Information

Product Name	(3S,4R)-4-(3-Fluorophenyl)Pyrrolidine-3-Carboxylic Acid
CAS No.	1049975-95-2
Molecular Formula	C11H12FNO2
Molecular Weight	209.22 g/mol
Synonyms	(3S,4R)-4-(3-Fluorophenyl)-3-pyrrolidinecarboxylic Acid; (3S,4R)-4-(3-Fluorophenyl)pyrrolidine-3-carboxylic acid; 4-(3-Fluorophenyl)-L-proline; (3S,4R)-4-(3-Fluorophenyl)-L-proline; 4-(3-Fluorophenyl)-D-proline (enantiomer); 3-Carboxy-4-(3-fluorophenyl)pyrrolidine; (3S,4R)-rel-4-(3-Fluorophenyl)pyrrolidine-3-carboxylic Acid
EINECS	Contact for details

Quality Control

Our (3S,4R)-4-(3-Fluorophenyl)Pyrrolidine-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) determination, to ensure compliance with exacting standards for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and residual solvent levels is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.