Description

(S)-α-(3-Nitro-Benzyl)-Proline Hcl is a high-purity chiral proline derivative, a critical building block in modern pharmaceutical synthesis. Its value lies in its role as a sophisticated intermediate for constructing complex molecules with defined stereochemistry, essential for developing active pharmaceutical ingredients (APIs). This compound is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of peptide-based therapeutics, enzyme inhibitors, and other novel drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel Active Pharmaceutical Ingredients (APIs), particularly in peptide and peptidomimetic drug discovery.
• Asymmetric Synthesis Catalyst/Organocatalyst: Used as a precursor or component in the design of chiral catalysts for enantioselective organic transformations.
• Chemical Biology Research: Employed in the synthesis of probes and inhibitors to study enzyme function and protein-protein interactions.
• Peptide Chemistry: Serves as a modified, non-proteinogenic amino acid residue for introducing structural constraints and specific functionalities into synthetic peptides.
• Agrochemical Research: Potential intermediate in the synthesis of chiral, biologically active compounds for crop protection.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic and medicinal chemistry laboratories worldwide.

Basic Information

Product Name	(S)-α-(3-Nitro-Benzyl)-Proline Hcl
CAS No.	1049743-40-9
Molecular Formula	C₁₂H₁₄N₂O₄·HCl
Molecular Weight	286.71 g/mol
Synonyms	(S)-1-[(3-Nitrophenyl)methyl]pyrrolidine-2-carboxylic acid hydrochloride; (S)-α-(3-Nitrobenzyl)proline hydrochloride; L-α-(3-Nitrobenzyl)proline HCl; (2S)-1-[(3-Nitrophenyl)methyl]-2-pyrrolidinecarboxylic acid hydrochloride; Proline, 1-[(3-nitrophenyl)methyl]-, hydrochloride, (S)-; (S)-N-[(3-Nitrophenyl)methyl]proline hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-α-(3-Nitro-Benzyl)-Proline Hcl is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity, suitable for demanding research and development applications. We adhere to current industry best practices, and a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.