Description

(S)-(2-Nitrobenzyl)-Proline-Hcl is a chiral proline derivative, a high-purity building block essential for advanced organic synthesis. Its value lies in its role as a key intermediate for constructing complex molecules with defined stereochemistry, crucial for developing active pharmaceutical ingredients (APIs) and other fine chemicals. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries engaged in asymmetric synthesis and medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the research and development of novel drug candidates, particularly in protease inhibitor and peptidomimetic synthesis.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for synthesizing specialized ligands used in enantioselective catalytic reactions.
• Peptide Chemistry: Used in the synthesis of modified peptides where the proline scaffold is functionalized with a nitrobenzyl protecting group.
• Agrochemical Research: Employed as a building block for creating chiral active ingredients with specific biological activity.
• Academic & Industrial R&D: Utilized in methodological studies and process chemistry for exploring new synthetic routes to chiral compounds.

Basic Information

Product Name	(S)-(2-Nitrobenzyl)-Proline-Hcl
CAS No.	1049742-66-6
Molecular Formula	C₁₂H₁₄N₂O₄·HCl
Molecular Weight	286.71 g/mol
Synonyms	(S)-1-(2-Nitrobenzyl)proline hydrochloride; (S)-1-[(2-Nitrophenyl)methyl]-L-proline hydrochloride; L-Proline, 1-[(2-nitrophenyl)methyl]-, hydrochloride (1:1); (S)-2-Nitrobenzyl-Proline Hydrochloride; Proline, (S)-(2-nitrobenzyl)-, hydrochloride; (S)-N-(2-Nitrobenzyl)proline HCl; (S)-1-(2-Nitrobenzyl)pyrrolidine-2-carboxylic acid hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-(2-Nitrobenzyl)-Proline-Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and production. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.