Description

(S)-α-(4-Methylbenzyl)-Proline-Hcl CAS NO 1049742-28-0 is a high-purity, non-natural amino acid derivative featuring a proline backbone with a chiral (S)-α-(4-methylbenzyl) substituent. This compound serves as a critical chiral building block and intermediate in the synthesis of complex pharmaceutical molecules, particularly in the development of protease inhibitors and other active pharmaceutical ingredients (APIs). It is essential for research and production teams in the pharmaceutical, biotechnology, and fine chemical sectors who require enantiomerically pure intermediates for advanced drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and commercial synthesis of novel drug candidates, especially protease inhibitors.
• Peptidomimetics Research: Used in the design and construction of peptide analogs and mimetics for medicinal chemistry studies.
• Asymmetric Synthesis: Employed as a chiral auxiliary or precursor in stereoselective chemical reactions to introduce specific chirality.
• API Development: Serves as a building block in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs).
• Bioconjugation & Labeling: Potential use in modifying peptides or proteins for diagnostic or therapeutic applications.
• Chemical Biology Probes: Useful for creating specialized probes to study enzyme function and biological pathways.

Basic Information

Product Name	(S)-α-(4-Methylbenzyl)-Proline Hydrochloride
CAS No.	1049742-28-0
Molecular Formula	C14H19NO2 • HCl
Molecular Weight	269.77 g/mol (Free base: 233.31 g/mol)
Synonyms	(S)-α-(4-Methylbenzyl)proline hydrochloride; (S)-1-[(4-Methylphenyl)methyl]-L-proline hydrochloride; (S)-A-(p-Tolylmethyl)proline HCl; L-Proline, 1-[(4-methylphenyl)methyl]-, hydrochloride (1:1), (S)-; (S)-1-(4-Methylbenzyl)proline hydrochloride; 1049742-28-0; (S)-α-(p-Methylbenzyl)proline HCl
EINECS	Contact for details

Quality Control

Our (S)-α-(4-Methylbenzyl)-Proline-Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. A Certificate of Analysis (COA) detailing purity, chiral excess, and impurity profiles is provided with every shipment. We adhere to cGMP principles where applicable to guarantee supply consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.