Description

(Trans)-4-(3-Thienyl)-Pyrrolidine-3-Carboxylic Acid-Hcl CAS NO 1049740-39-7 is a high-purity, heterocyclic building block featuring a pyrrolidine core substituted with a thienyl group and a carboxylic acid functionality. This compound is a critical chiral intermediate in modern pharmaceutical research and development, valued for its structural complexity and potential for creating novel bioactive molecules. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, including the synthesis of potential drug candidates targeting central nervous system disorders and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) drug discovery.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to develop new therapeutic compounds.
• Agrochemical Synthesis: Serves as a precursor in the development of advanced crop protection agents and pesticides.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and enzyme functions.
• Asymmetric Catalysis Ligand Precursor: The chiral pyrrolidine structure can be modified to create ligands for asymmetric synthesis.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes under cGMP conditions.

Basic Information

Product Name	(Trans)-4-(3-Thienyl)-Pyrrolidine-3-Carboxylic Acid Hydrochloride
CAS No.	1049740-39-7
Molecular Formula	C9H12ClNO2S
Molecular Weight	233.71 g/mol
Synonyms	(3R,4S)-4-(Thiophen-3-yl)pyrrolidine-3-carboxylic acid hydrochloride; (3R,4S)-4-(3-Thienyl)-3-pyrrolidinecarboxylic acid hydrochloride; trans-4-(3-Thienyl)pyrrolidine-3-carboxylic acid HCl; 4-(Thiophen-3-yl)pyrrolidine-3-carboxylic acid hydrochloride (trans); 1049740-39-7; (3R,4S)-4-(3-Thienyl)pyrrolidine-3-carboxylic acid hydrochloride
EINECS	Contact for details

Quality Control

Our (Trans)-4-(3-Thienyl)-Pyrrolidine-3-Carboxylic Acid-Hcl is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. We provide comprehensive analytical data, including HPLC purity, chiral purity, and identity confirmation. A detailed Certificate of Analysis (COA) is supplied with each batch, documenting compliance with customer specifications. Our quality system supports development under ICH guidelines, and custom synthesis can be performed to meet specific regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); containers must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.