Description

3-Pyrrolidinecarboxylic Acid, 4-(3-Cyanophenyl)-, Hydrochloride (1:1), (3S,4R)- is a high-purity, stereochemically defined chiral building block of significant interest in advanced organic synthesis. Its core value lies in its rigid pyrrolidine scaffold and functional handles, which are critical for constructing complex molecules with precise three-dimensional architecture. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for applications such as medicinal chemistry, process development, and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in central nervous system (CNS) and metabolic disease therapeutic areas.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization due to its constrained conformation and potential for hydrogen bonding.
• Agrochemical Synthesis: Serves as a building block for developing novel, stereospecific pesticides and herbicides with enhanced efficacy and selectivity.
• Catalyst and Ligand Development: The pyrrolidine core can be utilized to develop novel chiral catalysts or ligands for asymmetric synthesis.
• Chemical Biology Probe Synthesis: Employed in the creation of molecular probes to study biological pathways and protein function.
• Academic and Institutional Research: Used in universities and research institutes for methodological development in organic synthesis and stereochemistry.

Basic Information

Product Name	3-Pyrrolidinecarboxylic Acid, 4-(3-Cyanophenyl)-, Hydrochloride (1:1), (3S,4R)-
CAS No.	1049734-95-3
Molecular Formula	C12H13N2O2•HCl
Molecular Weight	252.71 g/mol
Synonyms	(3S,4R)-4-(3-Cyanophenyl)pyrrolidine-3-carboxylic acid hydrochloride; (3S,4R)-4-(3-Cyanophenyl)-3-pyrrolidinecarboxylic acid hydrochloride; 4-(3-Cyanophenyl)-L-proline hydrochloride (stereospecific); (3S,4R)-4-(3-Cyanobenzyl)proline hydrochloride; 1049734-95-3; (3S,4R)-PCA-3-CN-Ph HCl; 4-(m-Cyanophenyl)pyrrolidine-3-carboxylic acid HCl (stereoisomer)
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is characterized using advanced analytical techniques to confirm identity, purity, and stereochemical integrity. Certificates of Analysis (COA) are available upon request, detailing key parameters such as assay, chiral purity, and impurity profiles. We adhere to a cGMP-compliant quality management system for production relevant to pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to minimize exposure to atmospheric humidity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (3S,4R)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.