Description

(+/-)-trans-4-(4-Trifluoromethylphenyl)Pyrrolidine-3-Carboxylic Acid Hydrochloride is a high-purity, advanced pharmaceutical intermediate and building block of significant commercial interest. Its value lies in its unique pyrrolidine scaffold and trifluoromethylphenyl group, which are critical for modulating the biological activity, metabolic stability, and lipophilicity of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active ingredients targeting central nervous system (CNS) disorders, inflammation, and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel drug candidates, especially in neuroscience and psychiatric drug discovery.
• Protease Inhibitor Research: Used in the development of inhibitors for various protease enzymes due to its carboxylic acid functionality and rigid structure.
• Ligand Synthesis for Medicinal Chemistry: Serves as a precursor for creating complex ligands and molecular probes in structure-activity relationship (SAR) studies.
• Agrochemical Active Ingredient Development: Employed in the research phase for creating new herbicides or fungicides, leveraging the bioactivity of the trifluoromethyl group.
• Chemical Biology & Probe Development: Utilized to create tagged molecules for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring high-purity, complex heterocyclic compounds.

Basic Information

Product Name	(+/-)-trans-4-(4-Trifluoromethylphenyl)Pyrrolidine-3-Carboxylic Acid Hydrochloride
CAS No.	1049734-75-9
Molecular Formula	C12H13F3NO2 • HCl
Molecular Weight	295.69 g/mol (Free base: 260.23 g/mol)
Synonyms	trans-4-(4-(Trifluoromethyl)phenyl)pyrrolidine-3-carboxylic acid hydrochloride; (±)-trans-4-[4-(Trifluoromethyl)phenyl]-3-pyrrolidinecarboxylic acid hydrochloride; 4-(4-Trifluoromethyl-phenyl)-pyrrolidine-3-carboxylic acid hydrochloride (trans racemate); (3R*,4R*)-4-[4-(Trifluoromethyl)phenyl]pyrrolidine-3-carboxylic acid hydrochloride; (3S*,4S*)-4-[4-(Trifluoromethyl)phenyl]pyrrolidine-3-carboxylic acid hydrochloride; rac-trans-4-(4-Trifluoromethylphenyl)pyrrolidine-3-carboxylic acid HCl; TL01178 hydrochloride (potential research code)
EINECS	Contact for details

Quality Control

Our production of (+/-)-trans-4-(4-Trifluoromethylphenyl)Pyrrolidine-3-Carboxylic Acid Hydrochloride adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. All materials are characterized by advanced analytical techniques including HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.