Description

(R)-α-(3-Pyridinylmethyl)-Pro2Hcl CAS NO 1049732-88-8 is a high-purity chiral intermediate of significant importance in advanced pharmaceutical synthesis. This compound matters as a critical building block for the development of enantiomerically pure active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring high specificity. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel drugs, including potential treatments for neurological and metabolic disorders.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of enantiomerically pure active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Used as a building block in stereoselective chemical reactions to construct complex molecular architectures.
• Medicinal Chemistry Research: Serves as a crucial starting material or intermediate in drug discovery programs for hit-to-lead and lead optimization phases.
• Neurological Drug Development: Potential applications in synthesizing compounds targeting specific neurotransmitter pathways.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for the cGMP production of clinical trial materials and commercial APIs.
• Academic & Industrial R&D: Utilized in academic laboratories and industrial R&D departments for method development and novel synthetic route exploration.

Basic Information

Product Name	(R)-α-(3-Pyridinylmethyl)-Pro2Hcl
CAS No.	1049732-88-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	(R)-α-(3-Pyridylmethyl)-Proline Hydrochloride; (R)-α-(3-Pyridinylmethyl)-Proline HCl; (R)-α-(Pyridin-3-ylmethyl)proline hydrochloride; (R)-3-Pyridylmethyl-Proline HCl; (R)-A-(3-Pyridylmethyl)Proline Hydrochloride; (R)-Proline, α-(3-pyridinylmethyl)-, hydrochloride (1:1); (2R)-2-[(Pyridin-3-yl)methyl]pyrrolidine-2-carboxylic acid hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-α-(3-Pyridinylmethyl)-Pro2Hcl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including chiral purity verification by HPLC, to meet the stringent requirements of pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation from moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.