Description

(R)-α-(2-Trifluoromethyl-Benzyl)-Proline-Hcl is a high-purity, non-natural amino acid derivative featuring a chiral proline core and a trifluoromethyl-benzyl side chain. This compound is a critical chiral building block and intermediate in modern pharmaceutical research and development, particularly for the synthesis of novel active pharmaceutical ingredients (APIs). It is essential for medicinal chemists and process development scientists working in drug discovery, especially for projects targeting central nervous system (CNS) disorders, metabolic diseases, and enzyme inhibition.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of potential drug candidates, including protease inhibitors and receptor modulators.
• Peptidomimetics Research: Used to incorporate constrained, fluorinated motifs into peptide backbones to enhance metabolic stability, bioavailability, and binding affinity.
• Asymmetric Catalysis: Serves as a precursor or ligand for chiral catalysts in enantioselective synthesis.
• Chemical Biology & Proteomics: Employed in the design and synthesis of activity-based probes and molecular tools for studying enzyme function.
• Agrochemical Research: Investigated as an intermediate for developing advanced, chiral active ingredients with improved efficacy and environmental profiles.
• Academic & Contract Research: Utilized in university and CRO (Contract Research Organization) laboratories for exploratory chemistry and method development.

Basic Information

Product Name	(R)-α-(2-Trifluoromethyl-Benzyl)-Proline-Hcl
CAS No.	1049727-87-8
Molecular Formula	C13H14F3NO2 • HCl
Molecular Weight	309.71 g/mol (Free base: 273.25 g/mol)
Synonyms	(R)-α-(2-(Trifluoromethyl)benzyl)proline hydrochloride; (R)-1-[(2-Trifluoromethyl)phenyl]methyl]-L-proline hydrochloride; (R)-2-((2-(Trifluoromethyl)benzyl)amino)pentanedioic acid hydrochloride; (R)-Tfm-Bn-Pro-OH • HCl; (R)-2-Trifluoromethylbenzylproline HCl; (2R)-1-[(2-Trifluoromethylphenyl)methyl]pyrrolidine-2-carboxylic acid hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-α-(2-Trifluoromethyl-Benzyl)-Proline-Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements of pharmaceutical R&D. A detailed Certificate of Analysis (COA) providing results for identity, assay, chiral purity, and impurity profile is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.