Description

4-Chloro-6,7-Difluoro-Quinoline-3-Carboxylic Acid Amide is a high-purity, advanced pharmaceutical intermediate with significant synthetic utility. This compound is valued for its role as a key building block in the development of novel active pharmaceutical ingredients (APIs), particularly in the fields of oncology and anti-infective therapeutics. It is primarily sought by R&D chemists and process development scientists in the global pharmaceutical and fine chemical industries.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of complex quinoline-based drug candidates targeting various disease pathways.
• Anticancer Agent Research: Used in medicinal chemistry programs to develop novel kinase inhibitors and other targeted cancer therapies.
• Antimicrobial Development: Serves as a core scaffold for creating new antibiotics and antifungal agents, leveraging the bioactive quinoline structure.
• Agrochemical Synthesis: Employed in the research and production of advanced herbicides and pesticides with specific mode-of-action.
• Material Science Research: Investigated as a building block for organic electronic materials and fluorescent dyes due to its fused aromatic system.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	4-Chloro-6,7-Difluoro-Quinoline-3-Carboxylic Acid Amide
CAS No.	1049677-60-2
Molecular Formula	C₁₀H₅ClF₂N₂O
Molecular Weight	242.61 g/mol
Synonyms	4-Chloro-6,7-difluoroquinoline-3-carboxamide; 6,7-Difluoro-4-chloroquinoline-3-carboxylic acid amide; 3-Carbamoyl-4-chloro-6,7-difluoroquinoline; 4-Chloro-6,7-difluoro-3-quinolinecarboxamide; Quinoline-3-carboxamide, 4-chloro-6,7-difluoro-; 1049677-60-2; Amide of 4-Chloro-6,7-difluoro-quinoline-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our 4-Chloro-6,7-Difluoro-Quinoline-3-Carboxylic Acid Amide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment, ensuring compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound should be kept under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.