Description

Methyl 1-Cyclopropyl-6-Fluoro-8-Hydroxy-7-(3-Methylpiperazin-1-Yl)-4-Oxo-1,4-Dihydroquinoline-3-Carboxylate is a high-purity advanced pharmaceutical intermediate of significant commercial and research interest. Its complex molecular structure, featuring a fluoroquinolone core with a methylpiperazine substituent, makes it a critical building block in the synthesis of novel antibacterial agents. This compound is essential for pharmaceutical R&D teams and manufacturers focused on developing next-generation quinolone antibiotics to address evolving microbial resistance.

Application

• Pharmaceutical Intermediate: Primary use as a key synthetic precursor in the production of potent antibacterial fluoroquinolone drugs.
• Antibacterial Drug Development: Serves as a core scaffold for medicinal chemistry research aimed at creating new antibiotics with improved efficacy and safety profiles.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the final or penultimate steps of API manufacturing processes for target-specific antimicrobial therapies.
• Biochemical Research: Employed in microbiological and pharmacological studies to investigate structure-activity relationships (SAR) and mechanisms of action against bacterial DNA gyrase and topoisomerase IV.
• Process Chemistry & Scale-Up: Critical for process optimization and pilot-scale production runs in cGMP-compliant manufacturing facilities.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and regulatory submissions in drug development pipelines.

Basic Information

Product Name	Methyl 1-Cyclopropyl-6-Fluoro-8-Hydroxy-7-(3-Methylpiperazin-1-Yl)-4-Oxo-1,4-Dihydroquinoline-3-Carboxylate
CAS No.	1048972-33-3
Molecular Formula	C19H21FN4O4
Molecular Weight	388.39 g/mol
Synonyms	1-Cyclopropyl-6-fluoro-8-hydroxy-7-(3-methyl-1-piperazinyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid methyl ester; Methyl 1-cyclopropyl-6-fluoro-8-hydroxy-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylate; 7-(3-Methylpiperazin-1-yl)-1-cyclopropyl-6-fluoro-8-hydroxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid methyl ester; Quinolone Carboxylic Acid Ester Intermediate; Fluoroquinolone Intermediate CAS 1048972-33-3
EINECS	Contact for details

Quality Control

Our Methyl 1-Cyclopropyl-6-Fluoro-8-Hydroxy-7-(3-Methylpiperazin-1-Yl)-4-Oxo-1,4-Dihydroquinoline-3-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and structural identity consistent with pharmaceutical intermediate standards. Comprehensive Certificates of Analysis (COA) detailing purity, impurities, and other critical parameters are provided to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.