Description

(R)-1-(Dimethylcarbamoyl)Pyrrolidine-2-Carboxylic Acid CAS NO 1046139-15-4 is a high-purity, chiral proline derivative characterized by its dimethylcarbamoyl substituent. This compound serves as a critical building block and chiral auxiliary in advanced organic synthesis, enabling the creation of enantiomerically pure pharmaceuticals and bioactive molecules. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for developing novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting neurological and metabolic disorders.
• Asymmetric Synthesis: Employed as a chiral catalyst or ligand to induce stereoselectivity in complex organic reactions, such as aldol additions or Michael reactions.
• Peptidomimetics Research: Used in medicinal chemistry to design and synthesize proline-based peptidomimetics for drug discovery programs.
• Agrochemical Development: Intermediate in the production of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Chemical Biology Probes: Building block for creating labeled compounds and molecular probes used in biochemical and cellular studies.
• Custom Synthesis: Serves as a starting material for contract research organizations (CROs) and CDMOs performing bespoke synthesis for clients.

Basic Information

Product Name	(R)-1-(Dimethylcarbamoyl)Pyrrolidine-2-Carboxylic Acid
CAS No.	1046139-15-4
Molecular Formula	C9H16N2O3
Molecular Weight	200.24 g/mol
Synonyms	(R)-1-(N,N-Dimethylcarbamoyl)pyrrolidine-2-carboxylic acid; (R)-N,N-Dimethyl-2-pyrrolidinecarboxamide-2-carboxylic acid; (2R)-1-(Dimethylcarbamoyl)pyrrolidine-2-carboxylic acid; (R)-Proline, 1-(dimethylcarbamoyl)-; L-Proline, 1-(dimethylcarbamoyl)- (8CI); UNII-6K8J4QPV6S; 6K8J4QPV6S; (R)-1-Carboxy-N,N-dimethylpyrrolidine-2-carboxamide
EINECS	Contact for details

Quality Control

Our (R)-1-(Dimethylcarbamoyl)Pyrrolidine-2-Carboxylic Acid is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.