Description

2-(tert-Butoxycarbonyl)Isoindoline-4-Carboxylic Acid is a high-purity, protected amino acid derivative that serves as a critical building block in advanced organic synthesis. Its primary value lies in enabling the precise construction of complex molecules, particularly in the development of novel pharmaceuticals and bioactive compounds. This product is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality intermediates for peptide-mimetic and heterocyclic chemistry.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing isoindoline or constrained peptide backbones.
• Peptidomimetic Research: Used to introduce rigid, bicyclic structural motifs that mimic peptide conformations, aiding in drug discovery for metabolic and neurological targets.
• Protecting Group Strategy: The tert-butoxycarbonyl (Boc) group provides orthogonal protection for the secondary amine, facilitating complex multi-step synthetic sequences.
• Agrochemical Synthesis: Serves as a precursor for novel herbicides and fungicides that incorporate the isoindoline scaffold for enhanced bioactivity.
• Ligand and Catalyst Development: Employed in the creation of chiral ligands and organocatalysts for asymmetric synthesis applications.
• Material Science Precursor: Can be utilized in the synthesis of functionalized polymers and advanced organic materials with specific optical or electronic properties.

Basic Information

Product Name	2-(tert-Butoxycarbonyl)Isoindoline-4-Carboxylic Acid
CAS No.	1044764-69-3
Molecular Formula	C14H17NO4
Molecular Weight	263.29 g/mol
Synonyms	Boc-Isoindoline-4-carboxylic Acid; 1-Boc-1,3-dihydro-2H-isoindole-4-carboxylic acid; 2-[(tert-Butoxy)carbonyl]-2,3-dihydro-1H-isoindole-4-carboxylic acid; 4-Carboxy-1,3-dihydro-2H-isoindole-2-carboxylic acid tert-butyl ester; 2-(Boc)isoindoline-4-carboxylic acid; 1,3-Dihydro-2H-isoindole-4-carboxylic acid, 2-[(1,1-dimethylethoxy)carbonyl]-; 2-tert-Butoxycarbonyl-2,3-dihydro-1H-isoindole-4-carboxylic acid
EINECS	Contact for details

Quality Control

Our 2-(tert-Butoxycarbonyl)Isoindoline-4-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our production adheres to cGMP principles where applicable, ensuring a reliable supply for research and development as well as scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.