Description

(R)-tert-Butyl 3-(Aminomethyl)-4-Benzylpiperazine-1-Carboxylate is a high-purity chiral piperazine derivative, a critical building block in modern pharmaceutical synthesis. Its value lies in its role as a key intermediate for constructing complex molecules with specific stereochemistry, essential for developing active pharmaceutical ingredients (APIs). This compound is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics, particularly in areas requiring precise molecular architecture. We supply CAS 1041399-53-4 with a commitment to consistent quality and reliable global delivery.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and oncology targets.
• API Synthesis: Used in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs) where the (R)-configured aminomethyl-benzylpiperazine scaffold is required.
• Medicinal Chemistry Research: Serves as a versatile building block for constructing focused libraries of compounds for structure-activity relationship (SAR) studies.
• Asymmetric Synthesis: Employed in catalytic and stoichiometric asymmetric reactions to introduce chirality into target molecules.
• Process Chemistry Development: Used for scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Contract Manufacturing & Research (CMO/CRO): Supplied to organizations providing custom synthesis and development services to the pharmaceutical industry.

Basic Information

Item	Detail
Product Name	(R)-tert-Butyl 3-(Aminomethyl)-4-Benzylpiperazine-1-Carboxylate
CAS No.	1041399-53-4
Molecular Formula	C17H27N3O2
Molecular Weight	305.42 g/mol
Synonyms	(R)-1-Boc-3-(aminomethyl)-4-benzylpiperazine; (R)-tert-Butyl 3-(aminomethyl)-4-benzyl-1-piperazinecarboxylate; (R)-N-Boc-3-(aminomethyl)-4-benzylpiperazine; (3R)-1-[(2-Methylpropan-2-yl)oxycarbonyl]-3-(aminomethyl)-4-benzylpiperazine; (R)-3-(Aminomethyl)-4-benzylpiperazine-1-carboxylic acid tert-butyl ester; tert-Butyl (3R)-3-(aminomethyl)-4-benzylpiperazine-1-carboxylate; 1-Boc-3-((R)-aminomethyl)-4-benzylpiperazine
EINECS	Contact for details

Quality Control

Our (R)-tert-Butyl 3-(Aminomethyl)-4-Benzylpiperazine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC), chiral purity, and impurity profiles is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. Keep the container tightly sealed when not in use to minimize exposure to air and moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.