Description

2,6-Diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester hemioxylate is a high-value, spirocyclic building block and protected intermediate of significant interest in modern pharmaceutical research. Its unique constrained bicyclic structure makes it a critical component for medicinal chemists aiming to improve the potency, selectivity, and metabolic stability of new drug candidates. This compound is primarily sought after by R&D and process development teams within the pharmaceutical, biotechnology, and fine chemical sectors for the synthesis of novel therapeutics.

Application

• Pharmaceutical Intermediate: Serves as a key protected precursor in the synthesis of spirocyclic active pharmaceutical ingredients (APIs) and drug candidates.
• Medicinal Chemistry Scaffold: Used as a rigid, three-dimensional core structure for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Proteolysis Targeting Chimera (PROTAC) Development: Employed as a linker or component in the design of bifunctional molecules for targeted protein degradation.
• Peptidomimetic Synthesis: Incorporated into peptide analogs to enhance conformational stability and bioavailability.
• Chemical Biology Probes: Utilized in the creation of tool compounds for investigating biological pathways and target validation.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations for custom synthesis and scale-up projects.

Basic Information

Product Name	2,6-Diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester hemioxylate
CAS No.	1041026-71-4
Molecular Formula	C10H17N2O3 • 0.5 H2O
Molecular Weight	216.26 g/mol (anhydrous basis)
Synonyms	tert-Butyl 2,6-diazaspiro[3.3]heptane-2-carboxylate hemihydrate; 2,6-Diazaspiro[3.3]heptane-2-carboxylic acid, 1,1-dimethylethyl ester, hemihydrate; 2-(tert-Butoxycarbonyl)-2,6-diazaspiro[3.3]heptane hemioxylate; Boc-2,6-diazaspiro[3.3]heptane hemihydrate; Spiro[3.3]heptane-2,6-diamine, N2-Boc-protected, hemihydrate; 2-Boc-2,6-diazaspiro[3.3]heptane hemihydrate; (2,6-Diazaspiro[3.3]hept-2-yl)carboxylic acid tert-butyl ester hemioxalate
EINECS	Contact for details

Quality Control

Every batch of 2,6-Diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester hemioxylate is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and development. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity (typically ≥95% by HPLC), and impurity profile.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	3.0 - 6.0% (Theoretical for hemihydrate: ~4.2%)
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.