Description

4-Chloro-8-(Trifluoromethoxy)Quinoline-3-Carboxylic Acid Ethyl Ester is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This compound serves as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for therapeutic agents targeting complex diseases. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing next-generation products.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel quinoline-based drug candidates with potential anti-infective, anti-cancer, or CNS activity.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging the biological activity of the quinoline scaffold.
• Chemical Synthesis Building Block: Serves as a versatile substrate for further functionalization (e.g., hydrolysis, amidation, cross-coupling reactions) in medicinal chemistry.
• Material Science Research: Potential component in the development of specialty chemicals or functional materials due to its unique fluorinated structure.
• Contract Research & Development (CRO/CMO): Supplied to organizations engaged in custom synthesis and process development for client projects.

Basic Information

Product Name	4-Chloro-8-(Trifluoromethoxy)Quinoline-3-Carboxylic Acid Ethyl Ester
CAS No.	1040013-63-5
Molecular Formula	C₁₃H₉ClF₃NO₃
Molecular Weight	319.66 g/mol
Synonyms	Ethyl 4-Chloro-8-(trifluoromethoxy)quinoline-3-carboxylate; 4-Chloro-8-trifluoromethoxy-quinoline-3-carboxylic acid ethyl ester; 8-(Trifluoromethoxy)-4-chloroquinoline-3-carboxylic Acid Ethyl Ester; Quinoline-3-carboxylic acid, 4-chloro-8-(trifluoromethoxy)-, ethyl ester; CAS 1040013-63-5
EINECS	Contact for details

Quality Control

Our 4-Chloro-8-(Trifluoromethoxy)Quinoline-3-Carboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.