Description

1H-Pyrrolo[2,3-B]Pyridine-5-Carboxylic Acid, 4-Chloro-1-[[2-(Trimethylsilyl)Ethoxy]Methyl]- is a high-purity, advanced pharmaceutical intermediate with a protected carboxylic acid functionality. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with targeted biological activity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly in oncology and antiviral therapeutic areas.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of complex drug candidates, especially kinase inhibitors and other small molecule therapeutics.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities with improved potency and selectivity.
• Process Chemistry Development: Serves as a standardized, high-quality starting material for scaling up synthetic routes from laboratory to pilot plant and commercial production.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs and CROs for custom synthesis projects requiring this specific protected pyrrolopyridine scaffold.
• Academic Research: Employed in university and institutional labs for fundamental research in heterocyclic chemistry and the development of new synthetic methodologies.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine-5-Carboxylic Acid, 4-Chloro-1-[[2-(Trimethylsilyl)Ethoxy]Methyl]-
CAS No.	1039740-71-0
Molecular Formula	C14H19ClN2O3Si
Molecular Weight	326.85 g/mol
Synonyms	4-Chloro-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid; 4-Chloro-1-[[2-(trimethylsilyl)ethoxy]methyl]-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid; 4-Chloro-1-SEM-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid; 4-Chloro-1-SEM-7-azaindole-5-carboxylic acid; 4-Chloro-1-((2-(trimethylsilyl)ethoxy)methyl)-7-azaindole-5-carboxylic acid; 1039740-71-0; 4-Chloro-1-SEM-7-aza-indole-5-carboxylic acid
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine-5-Carboxylic Acid, 4-Chloro-1-[[2-(Trimethylsilyl)Ethoxy]Methyl]- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring a reliable supply for research and development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.