Description

3-(2,4-Difluorophenyl)-1H-Pyrazole-5-Carboxylic Acid is a high-purity fluorinated pyrazole derivative serving as a critical building block in advanced organic synthesis. This compound matters because it provides a versatile and reactive scaffold for constructing complex molecules, particularly in the development of novel active pharmaceutical ingredients (APIs). Pharmaceutical, agrochemical, and advanced materials researchers need this high-quality intermediate to drive innovation in drug discovery and specialty chemical applications. Our supply ensures consistent quality and reliable availability for your most demanding R&D and scale-up projects.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and pesticides, leveraging the bioactivity of the difluorophenyl-pyrazole core.
• Ligand and Catalyst Development: Serves as a precursor for designing specialized ligands in catalytic systems and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of advanced polymers and functional materials with specific electronic or photonic properties.
• Chemical Biology Probes: Utilized as a core structure for developing molecular probes to study biological pathways and enzyme functions.
• Custom Synthesis & Contract Manufacturing: Supplied as a high-purity starting material for custom synthesis services and scale-up production under cGMP guidelines.

Basic Information

Product Name	3-(2,4-Difluorophenyl)-1H-Pyrazole-5-Carboxylic Acid
CAS No.	1039053-05-8
Molecular Formula	C10H6F2N2O2
Molecular Weight	224.17 g/mol
Synonyms	1H-Pyrazole-5-carboxylic acid, 3-(2,4-difluorophenyl)-; 3-(2,4-Difluorophenyl)-1H-pyrazole-5-carboxylic acid; 5-Carboxy-3-(2,4-difluorophenyl)pyrazole; 2,4-Difluoro-β-(1H-pyrazol-5-yl)benzenepropanoic acid (tautomeric form); DFPPA; Difluorophenyl pyrazole carboxylic acid
EINECS	Contact for details

Quality Control

Every batch of 3-(2,4-Difluorophenyl)-1H-Pyrazole-5-Carboxylic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for pharmaceutical and advanced chemical synthesis. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles by HPLC, NMR, and MS is supplied with each shipment. Our quality commitment aligns with ICH guidelines and supports regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.