Description

6-Azaspiro[2.5]Octane-6-Carboxylic Acid, Phenylmethyl Ester is a high-value, synthetically versatile building block characterized by its unique spirocyclic and benzyl-protected amine-carboxylate structure. This compound is critical for research and development in advanced pharmaceutical chemistry, serving as a key intermediate in the synthesis of complex molecules. It is primarily sought after by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for constructing novel active pharmaceutical ingredients (APIs) and exploring new chemical entities.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Medicinal Chemistry Research: Used in scaffold hopping and structure-activity relationship (SAR) studies to develop new pharmacophores.
• Process Chemistry Development: Serves as a key starting material or intermediate in the scale-up and optimization of API synthesis routes.
• Proteolysis Targeting Chimera (PROTAC) Development: Potential use in constructing linkers or warheads for targeted protein degradation therapeutics.
• Chemical Biology Probes: Utilized in the creation of specialized molecular probes for studying biological pathways and enzyme function.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds for client R&D programs.

Basic Information

Product Name	6-Azaspiro[2.5]Octane-6-Carboxylic Acid, Phenylmethyl Ester
CAS No.	1037834-61-9
Molecular Formula	C15H19NO2
Molecular Weight	245.32 g/mol
Synonyms	Benzyl 6-azaspiro[2.5]octane-6-carboxylate; 6-(Benzyloxycarbonyl)-6-azaspiro[2.5]octane; 6-CBz-6-azaspiro[2.5]octane; 6-Azaspiro[2.5]octane-6-carboxylic acid benzyl ester; 1-CBz-1-azaspiro[2.5]octane; 1-Azaspiro[2.5]octane-1-carboxylic acid, benzyl ester; 6-N-CBz-6-azaspiro[2.5]octane; 1037834-61-9
EINECS	Contact for details

Quality Control

Our 6-Azaspiro[2.5]Octane-6-Carboxylic Acid, Phenylmethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with all shipments, detailing batch-specific results. Our quality commitment supports applications requiring high-purity intermediates for pharmaceutical R&D and cGMP development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.