Description

6-Bromo-2-Chloro-5-Fluoro-Quinazoline is a high-value, multi-halogenated quinazoline derivative that serves as a critical building block in advanced organic synthesis. Its precise halogen substitution pattern makes it an indispensable intermediate for constructing complex molecules with targeted biological activity. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of tyrosine kinase inhibitors (TKIs) and other targeted cancer therapeutics.
• Agrochemical Research: Used in the development of new herbicides and fungicides, leveraging the quinazoline core's bioactivity.
• Chemical Biology Probes: Serves as a scaffold for creating fluorescent or affinity probes to study enzyme function and drug-target interactions.
• Material Science: A starting material for synthesizing specialized organic electronic materials and liquid crystals.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of client-specific novel chemical entities (NCEs).

Basic Information

Product Name	6-Bromo-2-Chloro-5-Fluoro-Quinazoline
CAS No.	1036756-07-6
Molecular Formula	C8H3BrClFN2
Molecular Weight	261.48 g/mol
Synonyms	6-Bromo-2-chloro-5-fluoroquinazoline; 2-Chloro-6-bromo-5-fluoroquinazoline; 5-Fluoro-6-bromo-2-chloroquinazoline; Quinazoline, 6-bromo-2-chloro-5-fluoro-; 1036756-07-6; BCFQ
EINECS	Contact for details

Quality Control

Our 6-Bromo-2-Chloro-5-Fluoro-Quinazoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and process development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.