Description

2(1H)-Quinazolinone, 6-Bromo-5-Fluoro- is a high-purity, halogenated quinazolinone derivative serving as a critical synthetic intermediate in advanced pharmaceutical research and development. Its core value lies in enabling the construction of complex molecular architectures, particularly for targeted therapies. This compound is essential for medicinal chemists and process development scientists working in oncology, kinase inhibitor discovery, and other life science sectors requiring precise chemical building blocks.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel small-molecule drug candidates, particularly kinase inhibitors and targeted cancer therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its modifiable quinazolinone core.
• Chemical Biology: Serves as a precursor for developing chemical probes to study enzyme function and biological pathways.
• Process Chemistry: Employed in route scouting and scale-up development for Active Pharmaceutical Ingredient (API) manufacturing.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services for the pharmaceutical industry.

Basic Information

Product Name	2(1H)-Quinazolinone, 6-Bromo-5-Fluoro-
CAS No.	1036756-06-5
Molecular Formula	C8H4BrFN2O
Molecular Weight	243.04 g/mol
Synonyms	6-Bromo-5-fluoroquinazolin-2(1H)-one; 5-Fluoro-6-bromo-1,2-dihydroquinazolin-2-one; 6-Bromo-5-fluoro-1H-quinazolin-2-one; 6-Bromo-5-fluoro-2(1H)-quinazolinone; 5-Fluoro-6-bromoquinazolin-2(1H)-one; 1036756-06-5; 6-Bromo-5-fluoroquinazolinone
EINECS	Contact for details

Quality Control

Our 2(1H)-Quinazolinone, 6-Bromo-5-Fluoro- is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support development efforts with material produced to meet pharma-grade standards, with specifications customizable based on project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). The compound is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.