Description

(S)-2-(Boc-Amino)-2-(3-Trifluoromethylphenyl)Acetic Acid is a high-purity, non-natural amino acid derivative featuring a chiral center and a trifluoromethylphenyl group, making it a critical building block for advanced pharmaceutical synthesis. Its primary value lies in enabling the development of novel, biologically active compounds with enhanced metabolic stability and binding affinity. This intermediate is essential for research and production teams in medicinal chemistry, particularly those developing peptide-based therapeutics, enzyme inhibitors, and targeted drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for oncology and central nervous system (CNS) drugs.
• Peptidomimetics Construction: Used to incorporate non-natural, sterically hindered amino acid residues into peptide chains to improve proteolytic stability and pharmacokinetic properties.
• Protease Inhibitor Development: Serves as a core structure in designing potent inhibitors for various proteases due to the specific steric and electronic profile imparted by the trifluoromethylphenyl group.
• Chemical Biology Probes: Employed in the synthesis of labeled compounds and molecular probes for studying enzyme mechanisms and protein-ligand interactions.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or starting material in stereoselective synthesis to introduce chirality into complex molecular architectures.
• Agrochemical Research: Potential intermediate in the discovery of novel herbicides or pesticides with specific activity.

Basic Information

Product Name	(S)-2-(Boc-Amino)-2-(3-Trifluoromethylphenyl)Acetic Acid
CAS No.	1035490-76-6
Molecular Formula	C₁₅H₁₈F₃NO₄
Molecular Weight	333.31 g/mol
Synonyms	(S)-2-((tert-Butoxycarbonyl)amino)-2-[3-(trifluoromethyl)phenyl]acetic acid; Boc-(S)-3-(Trifluoromethyl)phenylglycine; (S)-2-(Boc-Amino)-2-(3-Trifluoromethylphenyl)Ethanoic Acid; N-Boc-3-Trifluoromethyl-D-phenylglycine; (S)-N-Boc-2-Amino-2-(3-trifluoromethylphenyl)acetic acid; (S)-2-(tert-Butoxycarbonylamino)-2-(3-trifluoromethylphenyl)acetic acid; BOC-3-CF3-D-PHG-OH
EINECS	Contact for details

Quality Control

Our (S)-2-(Boc-Amino)-2-(3-Trifluoromethylphenyl)Acetic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to meet the exacting standards of pharmaceutical R&D. A detailed Certificate of Analysis (COA) providing specifications for identity, purity (assay), chiral purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.