Description

Trifluoroacetato[4,5-Dihydro-1,3-Bis(2,4,6-Trimethylphenyl)Imidazol-2-Ylidene] Tetra(2,2-Dimethylpropanenitrile)Ruthenium(II) Trifluoroacetate is a highly specialized, second-generation Grubbs-Hoveyda type olefin metathesis catalyst. This compound is valued for its enhanced thermal stability and excellent functional group tolerance, enabling efficient and selective carbon-carbon double bond formation in complex molecular architectures. It is an essential tool for R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors, where precision and reliability in synthetic transformations are paramount.

Application

• Pharmaceutical Intermediate Synthesis: Key catalyst for ring-closing metathesis (RCM), cross metathesis (CM), and ring-opening metathesis polymerization (ROMP) in the production of active pharmaceutical ingredients (APIs).
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides requiring complex cyclic or macrocyclic structures.
• Polymer & Material Science: Enables the production of specialty polymers, functionalized surfaces, and self-healing materials via controlled ROMP reactions.
• Fine Chemical Manufacturing: Facilitates the efficient construction of complex organic molecules for fragrances, flavors, and electronic chemicals.
• Academic & Industrial R&D: A critical reagent for methodology development and exploring new synthetic routes in organic chemistry laboratories.
• Process Chemistry Optimization: Employed in scaling up metathesis reactions from milligram to kilogram scale due to its robust performance.

Basic Information

Product Name	Trifluoroacetato[4,5-Dihydro-1,3-Bis(2,4,6-Trimethylphenyl)Imidazol-2-Ylidene] Tetra(2,2-Dimethylpropanenitrile)Ruthenium(II) Trifluoroacetate
CAS No.	1034198-65-6
Molecular Formula	C46H57F6N7O4Ru
Molecular Weight	1010.08 g/mol
Synonyms	Grubbs-Hoveyda Catalyst 2nd Generation, Trifluoroacetate Salt; Hoveyda-Grubbs Catalyst II; (H2IMes)(pyr)2(Cl)2Ru=CHPh; [1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro(o-isopropoxyphenylmethylene)ruthenium(II) (related precursor); Zhan Catalyst 1B; Ru-Metathesis Catalyst; (SIMes)Ru(CF3CO2)(=CH-2-(2-PrO)-C6H4)(NCCH2C(CH3)3)4+ CF3CO2-
EINECS	Contact for details

Quality Control

Every batch of our ruthenium metathesis catalyst is produced and tested under strict quality control protocols to ensure consistency and performance. We provide comprehensive Certificates of Analysis (COA) detailing key parameters such as purity (by NMR/HPLC), residual solvent content, and catalyst activity. Our manufacturing aligns with cGMP principles where applicable, supporting its use in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C. This material is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures will degrade performance. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Brown to purple crystalline solid or powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Active Ruthenium Content	≥ 9.8%
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.